For links to paper pdf files, and additional publications, click here

Selected publications:

Wilcockson, S. G., Sutcliffe, C. and Ashe, H. L. (2017) ‘Control of signaling molecule range during developmental patterning’, Cell Mol Life Sci 74(11): 1937-1956.
PMID: 27999899

Ashe, H. L. (2016) ‘Modulation of BMP signalling by integrins’, Biochemical Society Transactions 44(5): 1465-1473.
PMID: 27911728

Deignan, L., Pinheiro, M. T., Sutcliffe, C., Saunders, A., Wilcockson, S. G., Zeef, L. A., Donaldson, I. J. and Ashe, H. L. (2016) ‘Regulation of the BMP Signaling-Responsive Transcriptional Network in the Drosophila Embryo’, PLoS Genetics 12(7): e1006164.
PMID: 27379389

Sawala A, Scarcia M, Sutcliffe C, Wilcockson SG, Ashe HL. (2015) ‘Peak BMP Responses in the Drosophila Embryo Are Dependent on the Activation of Integrin Signaling’, Cell reports 12(10): 1584-1593.
PMID: 26321638

Newton FG, Harris RE, Sutcliffe C, Ashe HL. (2015) ‘Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development’, Development 142(19): 3362-3373.
PMID: 26293305

Winstanley, J., Sawala, A., Baldock, C. and Ashe, H. L. (2015) ‘Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation’, Elife 4.
PMID: 25642644

Dunipace, L., Saunders, A., Ashe, H. L. and Stathopoulos, A. (2013) ‘Autoregulatory Feedback Controls Sequential Action of cis-Regulatory Modules at the brinker Locus’, Developmental Cell 26(5): 536-543.
PMID: 24044892

Saunders, A. and Ashe, H. L. (2013) ‘Taking a Pause to Reflect on Morphogenesis’, Cell 153(5): 941-943.
PMID: 23706731

Saunders, A., Core, L. J., Sutcliffe, C., Lis, J. T. and Ashe, H. L. (2013) ‘Extensive polymerase pausing during Drosophila axis patterning enables high-level and pliable transcription’, Genes & Development 27(10): 1146-1158.
PMID: 23699410

Sawala, A., Sutcliffe, C. and Ashe, H. L. (2012) ‘Multistep molecular mechanism for Bone morphogenetic protein extracellular transport in the Drosophila embryo’, Proceedings of the National Academy of Sciences of the United States of America 109(28): 11222-11227.
PMID: 22733779

Fritsch, C., Sawala, A., Harris, R., Maartens, A., Sutcliffe, C., Ashe, H. L. and Ray, R. P. (2012) ‘Different Requirements for Proteolytic Processing of Bone Morphogenetic Protein 5/6/7/8 Ligands in Drosophila melanogaster’, Journal of Biological Chemistry 287(8): 5942-5953.
PMID: 22199351

Yarunin, A., Harris, R. E., Ashe, M. P. and Ashe, H. L. (2011) ‘Patterning of the Drosophila oocyte by a sequential translation repression program involving the d4EHP and Belle translational repressors’, RNA Biology 8(5): 904-912.
PMID: 21788736

Harris, R. E. and Ashe, H. L. (2011) ‘Cease and desist: modulating short-range Dpp signalling in the stem-cell niche’, EMBO Reports 12(6): 519-526.
PMID: 21546910

Harris, R. E., Pargett, M., Sutcliffe, C., Umulis, D. and Ashe, H. L. (2011) ‘Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling’, Developmental Cell 20(1): 72-83.
PMID: 21238926

Ashe, H. L. (2008) ‘Type IV collagens and Dpp Positive and negative regulators of signaling’, Fly 2(6): 313-315.
PMID: 19077532

Miles, W. O., Jaffray, E., Campbell, S. G., Takeda, S., Bayston, L. J., Basu, S. P., Li, M. F., Raftery, L. A., Ashe, M. P., Hay, R. T. and Ashe, H. L. (2008) ‘Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo’, Genes & Development 22(18): 2578-2590.
PMID: 18794353

Wang, X. M., Harris, R. E., Bayston, L. J. and Ashe, H. L. (2008) ‘Type IV collagens regulate BMP signalling in Drosophila’, Nature 455(7209): 72-U49.
PMID: 18701888

Ashe, H. L. and Briscoe, J. (2006) ‘The interpretation of morphogen gradients’, Development 133(3): 385-394.
PMID: 16410409

Ashe, H. L. (2005) ‘BMP signalling: Synergy and feedback create a step gradient’, Current Biology 15(10): R375-R377.
PMID: 15916937

Wharton, S. J., Basu, S. P. and Ashe, H. L. (2004) ‘Smad affinity can direct distinct readouts of the embryonic extracellular Dpp gradient in Drosophila’, Current Biology 14(17): 1550-1558.
PMID: 15341741

Ashe, H. L. (2002) ‘BMP signalling: Visualisation of the sog protein gradient’, Current Biology 12(8): R273-R275.
PMID: 11967165